Patient Database

Limited epidemiological information is available concerning patients with osteonecrosis. This is a reflection of the relatively small number of patients seen at any one institution. A collaborative effort between multiple centers is needed. Questionnaires and data sheets have been developed to collect demographic information from patients at multiple institutions. This information is then entered into a computerized database. We are currently recruiting physicians to participate in this project. It is anticipated that additional patients may be added through contact initiated through the Internet.

Alcohol Intake and Cigarette Smoking

We are currently engaged in a multicenter study to evaluate the incidence of alcohol intake and cigarette smoking in patients with osteonecrosis in the United States.

Core Decompression Studies

One of the surgical treatments for the early stages of osteonecrosis is core decompression. This procedure is effective in the relief of pain and, in some patients, may halt the progression of the disease. This procedure involves the removal of a core of bone from the femoral head. The core tract can then be left alone or filled with bone graft, a bone graft substitute, or metal implant. We are engaged in the ongoing study of a number of bone graft materials. Patient enrollment is complete; no new patients are being entered at this time. Watch for updates on open enrollment in new studies.

Basic Science

One of the major aims of the Center for Osteonecrosis Research and Education is to conduct basic science experiments pertaining to the pathogenesis of this disease process. Both in vitro and in vivo models will be explored. There are three projects currently underway.

Project One is the evaluation of the effect of mechanical stimulation on bone cells that have been exposed to corticosteroid.

Project Two is the histological evaluation of angiogenic factors in osteonecrotic femoral head samples using in situ hybridization.

Project Three is the histological examination of osteonecrotic human femoral head specimens in comparison to osteoarthritis with respect to fat cell morphology and the presence/absence of thrombi.